Epithalon (Epitalon) 10mg, 20mg & 50mg
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$65.00 – $215.00
Epithalon (Epitalon) is a synthetic derivative of Epithalamin and a potential modulator of telomerase, the enzyme that maintains and protects the telomere caps at the ends of chromosomes (strands of DNA). Research suggests that Epithalon induces telomere elongation and may fight off the effects of aging as a result.
Epithalon is a research peptide and is also known as Epitalon and Epithalone. Still being studied, results have shown it to show benefits in reducing age-related symptoms and illnesses. Including improving heart and metabolic processes and extending longevity in humans.
Epithalon is a research chemical that regulates the cell cycle and increases telomerase activity. Research from experiments has discovered it could prevent the development of series diseases including, Alzheimer’s disease, diabetes, coronary diseases, and pulmonary fibrosis. Research is still in progress.
Epithalon is a research peptide and controls the function of cells by stimulating the production of telomerase, which replenishes cells and allows for the growth of new cells. This has shown positive results in reducing age-related diseases and slowing down the deterioration of organs in the body. Studies still continue to prove the safety and effectiveness of the chemical.
PRODUCT USAGE WARNING : This PRODUCT IS INTENDED AS A RESEARCH CHEMICAL ONLY. This designation allows the use of research chemicals strictly for in vitro testing and laboratory experimentation only. All product information available on this website is for educational purposes only. Bodily introduction of any kind into humans or animals is strictly forbidden by law. This product should only be handled by licensed, qualified professionals. This product is not a drug, food, or cosmetic and may not be misbranded, misused or mislabled as a drug, food or cosmetic.
Description
BUY EPITHALON EPITALON PEPTIDE FOR SALE ONLINE
What Is Epithalon?
Epithalon (also known as Epitalon, Epithalone or Epithalamin) is a short synthetic peptide known to activate the telomerase enzyme and stimulate melatonin release. First developed in Russia in the 1980s, epithalon has been shown to delay age-related changes in reproductive and immune systems and increase the life span of mice and rats. Though it is primarily of interest in anti-aging research, epithalon has shown significant effects in certain types of cancer, infectious disease, and in DNA regulation.
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Epithalon Structure
Source: PubChem
Sequence: Ala-Glu-Asp-Gly
Molecular Formula: C14H22N4O9
Molecular Weight: 390.349 g/mol
PubChem CID: 219042
CAS Number: 307297-39-8
Epithalon Research
1. The Role of Telomerase in the Anti-Aging Effects of Epithalon
Early research using insects and rodents revealed that epithalon can prolong life substantially. In normal, healthy fruit flies and rats, epithalon decreases mortality by 52%. In mice prone to both heart disease and cancer, epithalon prolongs life by as much as 27% compared to controls. At least part of the answer to how epithalon achieves these profound effects is via its elimination of free radicals (charged molecules that do damage to healthy tissue).
Anti-oxidant activity is not the only reason that epithalon extends life, however. There is good evidence from in vitro experiments on human somatic cells to show that epithalon activates an enzyme called telomerase. Telomerase protects telomeres, the ends of chromosomes that are critical to ensuring the health of DNA. Epithalon’s activation of telomerase leads directly to a decrease in how many errors a strand of DNA contains, supporting the notion that epithalon protects DNA from damage. In short, epithalon protects DNA from accumulating errors over time, a process that eventually leads to cell dysfunction, aging, and even cancer in some cases.
2. Epithalon and DNA Activation
Neither its impact on free radicals nor its effects on telomeres seem sufficient to explain the profound effects that epithalon has on longevity. Indeed, scientists are working hard to understand how this short peptide achieves the effects that it does so that the mechanisms can be explored in depth. As it turns out, at least part of the answer may come from the fact that epithalon changes the expression of certain genes.
Research in cell cultures shows that epithalon interacts directly with DNA to turn on and enhance the expression of certain genes. Epithalon interacts with the promoter regions of genes for CD5, IL-2, MMP2, and Tram1. CD5 and IL-2 both affect the function of the immune system while MMP2 plays a critical role in the maintenance of extracellular matrix in skin, tendons, and other connective tissue. These findings suggest that epithalon may impact the function of the immune system and the ability of the body to heal itself following not only injury, but following typical day-to-day stress as well.
It is not surprising that epithalon impacts the immune system. Research in rats indicates that epithalon boost the expression of interferon gamma in aging lymphocytes. Interferon gamma is a critical signaling molecule in the immune system. It is important for fighting off viral infections through the activation of macrophages, natural killer cells, and T cells.
The following are known DNA interactions of epithalon:
- CD5 – Leads to immune cell differentiation
- IL-2 – Increases IL-2 production, which regulates white blood cells
- MMP2 – Enhances MMP activation and decreases inflammation
- Tram1 – Enhances protein production
- Arylalkylamine-N-acetyltransferase – Enhances melatonin production
- pCREB t – Circadian rhythm regulation and anti-neoplastic effects
- Telomerase – Telomerase activity increases cell longevity
3. Epithalon and Skin Health
As stated above, epithalon has a positive effect on the gene that regulates MMP2. MMP2 is a protein found in connective tissue like skin. Research in rodents indicates that not only does epithalon activate this gene, it activates fibroblasts, the cells that produce and maintain MMP2 as well as other components of the extracellular matrix like collagen and elastin. Mice exposed to epithalon show an increase in fibroblast activation of 30-45%. By activating fibroblasts, epithalon can help to boost rates of healing and offset the natural decline in skin structure and integrity that occurs with aging.
Further evidence for epithalon’s benefit in skin comes from the fact that it decreases caspase-3 activity. Caspase-3 is an enzyme in the apoptosis or programmed cell death pathway. By decreasing caspase-3 activity, epithalon helps to protect fibroblasts and other skin cells, keeping them alive and healthy for longer periods of time.
4. Epithalon and Tumor Growth
Daily administration of epithalon to rats with cancer has been found to decrease tumor growth. Not only does the peptide reduce tumor growth, it prevents the metastasis or spread of these tumors to distant tissues as well. Epithalon is currently being investigated as a potential treatment for Her-2/neu positive breast cancers and is of interest in preventing the development of certain types of leukemia as well as testicular cancer.
Slowed tumor growth in mice exposed to epithalon compared to controls
Source: Wiley Online Library
There is some evidence that epithalon activates the gene for PER1 protein, which is found in the hypothalamus. PER1, which helps to regulate circadian rhythm, is under-expressed in cancer patients. It is unclear if this under-expression precedes cancer development and therefore contributes to cancer growth or is a consequence of cancer development. It is clear that the protein affects cancer growth once the cancer is established. Control of PER1 expression may be one means of naturally slowing tumor growth. Research shows that PER1 expression sensitizes cells to the effects of radiation and may therefore help to decrease the doses of radiation needed to treat certain cancers, a fact that would not only offset immediate side effects, but reduce the occurrence of secondary tumors following high doses of radiation.
PER1 Causes Increased Rates of Ionizing Radiation-Induced Cell Death
Source: Molecular Cell
5. Epithalon and Melatonin Secretion
Melatonin, which is linked to sleep and aging, is produced by the pineal gland. Research in rats shows that epithalon and similar peptides affect both the synthesis and release of melatonin by affecting the expression of two proteins (arylalkylamine-N-acetyltransferase (AANAT) and pCREB transcription protein). Both of these genes play an important role in melatonin production and in the circadian (day/night) control of melatonin release. Research in monkeys indicates that epithalon restores melatonin secretion to normal.
6. Epithalon and Eyesight
A trial in rats suffering from retinitis pigmentosa found that epithalon improves outcomes in 90% of patients. It appears that the peptide helps to preserver normal structure of the eye while boosting the bioelectric function of the retina necessary for vision.
Epithalon exhibits minimal side effects, low oral and excellent subcutaneous bioavailability in mice. Per kg dosage in mice does not scale to humans. Epithalon for sale at USA Peptide Store is limited to educational and scientific research only, not for human consumption. Only buy Epithalon if you are a licensed researcher.
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At USA Peptide Store, our research peptides are of the highest purity and pharmaceutical grade. Our Epithalon Epitalon peptide comes in 10mg, 20mg and 50mg. We’re passionate about our products, and we always strive to provide our customers with the best in both selection and quality. All of the products we provide are tested to verify authenticity and purity, so you can conduct your research with confidence.
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Additional Information
| Quantity | 10 mg, 20 mg, 50 mg |
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